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Search Results for " major depressive disorder "

22

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15799	LY2940094 LY-2940094	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	LY2940094 (LY-2940094) 是一种口服有效的选择性 NOP 受体拮抗剂，可降低动物模型的自身给药酒精依赖，对 NOP 受体具有高亲和力，Ki 为 0.105 nM，和拮抗活力，Kb 为 0.166 nM。
T1279	Vilazodone 维拉佐酮,SB659746A,EMD 68843	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Vilazodone (SB659746A) 是一种可口服的选择性 5 -羟色胺再摄取抑制剂 (SSRI) 和部分5-HT1A 受体激动剂。它有抗抑郁作用，可用于抑郁症和情绪性疾病的研究。
T27599	Imiloxan RS21361,RS 21361,RS-21361
	Imiloxan, an α2 adrenergic receptor antagonist, is used potentially for the treatment of major depressive disorder.
T7061	Duloxetine	Serotonin Transporter	Neuroscience
	Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。
T68172	Zalospirone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zalospirone 是一种5-HT1A 受体激动剂，可用于研究焦虑症和重度抑郁症。
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T6232	Vilazodone Hydrochloride 盐酸维拉佐酮,SB659746A,EMD 68843,Vilazodone HCl	Others; 5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience; Others
	Vilazodone Hydrochloride (EMD 68843) 是 5-HT1A 受体和特异性 5-羟色胺再摄取抑制剂(SSRI) 的部分激动剂，用于治疗重度抑郁症。
T22442	Trazodone 曲唑酮,AF-1161	5-HT Receptor	GPCR/G Protein; Neuroscience
	Trazodone (AF-1161) 是一种 5-HT 2A/2C 受体拮抗剂，用作治疗主要焦虑症和抑郁症的抗抑郁药。
T32737	Liafensine BMS820836,BMS 820836,DB104,BMS-820836	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Liafensine(BMS-820836) 是一种新型且具有选择性的三重单胺再摄取抑制剂，对血清素、去甲肾上腺素和多巴胺的再摄取具有抑制作用，可用于研究重度抑郁症和中枢神经系统疾病。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
T64317	ZZL-7	Serotonin Transporter	Neuroscience
	ZZL-7是一种起效快的抗抑郁药。ZZL-7破坏中缝背核（DRN）神经元一氧化氮合酶（nNOS）和血清素转运蛋白（SERT）之间的相互作用。ZZL-7可以很容易地穿过血脑屏障。ZZL-7在重度抑郁症（MDD）中具有研究价值。
T69364	Elzasonan
	Elzasonan is a selective 5-hydroxytryptamine 1B receptor antagonist used to treat patients with major depressive disorder and obsessive compulsive disorder.
T27939	LY2940094 tartrate LY2940094,LY 2940094,LY-2940094 tartrate,LY-2940094
	LY-2940094, a nociceptin receptor antagonist, is used potentially for the treatment of major depressive disorder and alcoholism.
T69063	Orvepitant
	Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia.
T71389	Fluoxetine oxalate
	Fluoxetine oxalate is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.
T71587	Fluoxetine succinate ester
	Fluoxetine succinate ester is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.
T27331	Flerobuterol HCl CRL-40996,CRL40996,CRL 40996,Flerobuterol hydrochloride
	Flerobuterol is a β adrenergic receptor agonist potentially for the treatment of major depressive disorder. Flerobuterol enhances serotonergic neurotransmission. Flerobuterol acutely increases 5-HT synthesis, in part, through an elevation of brain Trp ava
T68579	Fluvoxamine acid
	Fluvoxamine acid is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the treatment of obsessive-compulsive disorder (OCD), and is also used to treat major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).
T11113	Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride	Others	Others
	Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i
T68973	EVT-101 free base
	EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder. It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.
T79229	ETAP	Monoamine Oxidase	Neuroscience
	ETAP为一种既抑制MAO-A也抑制MAO-B的化合物，展现出抗抑郁样活性，可应用于重度抑郁症的研究领域。
T61008	(±)-Duloxetine hydrochloride
	(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride 是 Duloxetine hydrochloride 的外消旋物。Duloxetine hydrochloride 可用于研究糖尿病性神经性疼痛、纤维肌痛和重度抑郁症，它是 5-羟色胺去甲肾上腺素再摄取的抑制剂。

化合物

Cat.No: T15799

Synonym: LY-2940094

Target: Opioid Receptor

Cat.No: T1279

Synonym: 维拉佐酮,SB659746A,EMD 68843

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T27599

Synonym: RS21361,RS 21361,RS-21361

Cat.No: T7061

Target: Serotonin Transporter

Cat.No: T68172

Target: 5-HT Receptor

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Vilazodone Hydrochloride

Cat.No: T6232

Synonym: 盐酸维拉佐酮,SB659746A,EMD 68843,Vilazodone HCl

Target: Others, 5-HT Receptor, Serotonin Transporter

Cat.No: T22442

Synonym: 曲唑酮,AF-1161

Target: 5-HT Receptor

Cat.No: T32737

Synonym: BMS820836,BMS 820836,DB104,BMS-820836

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

Cat.No: T64317

Target: Serotonin Transporter

Cat.No: T69364

LY2940094 tartrate

Cat.No: T27939

Synonym: LY2940094,LY 2940094,LY-2940094 tartrate,LY-2940094

Cat.No: T69063

Fluoxetine oxalate

Cat.No: T71389

Fluoxetine succinate ester

Cat.No: T71587

Flerobuterol HCl

Cat.No: T27331

Synonym: CRL-40996,CRL40996,CRL 40996,Flerobuterol hydrochloride

Fluvoxamine acid

Cat.No: T68579

Duloxetine D3 hydrochloride

Cat.No: T11113

Synonym: (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride

Target: Others

EVT-101 free base

Cat.No: T68973

Cat.No: T79229

Target: Monoamine Oxidase

(±)-Duloxetine hydrochloride

Cat.No: T61008

Cat. No.	Product Name	Target	Signaling Pathways
T7475	S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸	Others; Endogenous Metabolite	Metabolism; Others
	S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的口服具有活力的甲基供体，能够用于肝病和骨关节炎的研究。

天然产物

S-Adenosyl-L-methionine

Cat.No: T7475

Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸

Target: Others, Endogenous Metabolite

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